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ASSESSMENT OF RHEOLOGICAL PROPERTIES OF BLOOD AS A FUNCTION OF HEALTH STATUS: A NOVEL POINT OF CARE DEVICE FOR POPULATION BASED SCREENING

Siddharth Singh Yadav
Amity University Noida India

Basant Singh Sikarwar
Department of Mechanical Engineering, Amity University Uttar Pradesh, Noida, U.P., India

Priya Ranjan
Department of Electrical and Electronic Engineering, Amity University Uttar Pradesh, NOIDA India

Rajiv Janardhanan
Amity Institute of Public Health, Amity University Uttar Pradesh, NOIDA India

DOI: 10.1615/TFEC2019.bio.028010
pages 797-802


键词 Rheological, Viscosity, Non-Newtonian

摘要

Blood is non-Newtonian shear thinning fluid. The physical properties of this important connective tissue known to vary, has potential application as a point of care device to assess the health of the populace in resource limited settings such as the Indian sub-continent. Indeed, vascular diseases are known to induce variations in the rheological attributes of blood stains. Taken together with inherent variances in the genetic base across the Indian sub-continent, we believe that the correlation of the variances in rheological properties of blood could be used effectively for preliminary screening of a health status of a community using minimally invasive techniques and hence can be prospected as a tool for low end affordable healthcare technologies. The simple point of care device developed by our group consists of a simple, robust and low-cost micro-fluidic device comprising of a micro-capillary viscometer attached to a pendant drop tensiometer, designed and fabricated to measure the viscosity, surface tension and wettability gradient of blood samples. Data generated from this device was classified using an automated nonlinear algorithm. We propose a novel, precision oriented, and fruganomic intervention for rapid assessment of health status of human beings. The device is portable and can be exploited for rapid screening of population in health camps. The framework for this portable device has enormous potential to be used for rapid screening of health status in resource limited settings abundantly found in low and middle income countries.

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