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AN ANALYTICAL MODEL TO DETERMINE THE MAXIMUM ALLOWABLE POINT SOURCE HEATING WITH MINIMAL RISK TO PHASE-CHANGE OF LIQUIDS IN BRAIN TISSUE

Smreeti Dahariya
Department of Mechanical and Nuclear Engineering, Kansas State University, Kansas, USA, 66506

Amy Rachel Betz
Department of Mechanical and Nuclear Engineering, Kansas State University, Kansas 66506, USA

DOI: 10.1615/TFEC2019.fnd.027388
pages 997-1007


键词 chemotherapy, drug delivery, conductive nano fibers, blood perfusion

摘要

The application of localized heat therapies like heating and cooling of biological tissue can be an important and effective way to treat/cure diseases, enhance and control drug delivery, and augment other forms of treatment such as chemotherapy. In today's health care, heating treatments regulate the blood flow and enhance the circulation of living tissue as well as provide oxygen. On the other hand, the cooling techniques provide a reverse effect on blood flow and tissue metabolism activities. In the recent advancements in nanotechnology, the fabrication of conductive nanofibers holds a great challenge for researchers to understand an interaction between the sensitiveness of tissue and stiffness of Nano/Micro-devices. In clinical applications, conductive nanofibers can be used as a point/line source of heating in tissue such as the brain [1]. The objective of the research work is to determine the maximum allowable point source heating with minimal risk to a phasechange of liquids in brain tissue. Penne's bio-heat transfer model is used to formulate energy balance in the brain tissue considering an external heat source, metabolic heat generation, and blood perfusion. The present work provides a fundamental new insight into the field of design and development of Nano-devices in many clinical uses.

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