In this work is presented an analytical review of experimental studies of hydraulic resistance and heat transfer in channels with intensifiers in the form of systems of spherical protrusions in a wide range of operating and design parameters. A common approach to the generalization of the experimental data of various authors is elaborated taking into account differences in the geometry of the heat transfer surfaces. Cross functional generalized characteristics for coefficients of hydraulic resistance and heat transfer in channels with spherical protrusions are obtained.