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ISSN Online: 2379-1748

ISBN Flash Drive: 978-1-56700-472-4

ISBN Online: 978-1-56700-471-7

3rd Thermal and Fluids Engineering Conference (TFEC)
March, 4–7, 2018, Fort Lauderdale, FL, USA

RHEOLOGICAL ANALYSIS OF CELL EMBEDDED HYDROGEL BIO-INK FOR EXTRUSION BIOPRINTING

Get access (open in a dialog) pages 1193-1196
DOI: 10.1615/TFEC2018.rhe.021751

Аннотация

Bioprinting is the process of additive manufacturing to form a tissue from biomaterials containing living cells. Biomaterials are mixed with cells to form a bioink. Bioinks aim to mimic the extracellular matrix, to support proliferation, differentiation and survival of the cells. The survival of the cells, structural integrity and printability relies heavily on the physicochemical properties of the bioink such as gelation, surface tension, viscosity etc. Rheological analysis of the bioink will provide valuable information about mechanical properties such as the viscosity, shear stress and shear rate. These mechanical properties of the bioink before, after and during printing are important parameters in determining the printability of the 3D structure. The objective of this paper is to investigate the properties of the bioink composed of sodium alginate and gelatin along with Human umbilical vein endothelial cells (HUVECs) in order to determine the ideal matrix composition for 3D structures for vascular applications. Rheological properties of the composite hydrogel will be evaluated using DV3T viscometer from Brookfield Laboratories.