The paper reports the result of an experimental study related to the effects of inclination on pressure drop in an upward, isothermal, co-current, two-phase (air/water) flow pipe system. Experimental data for the investigation were acquired using an inclinable flow loop equipped with a 101.6 mm, inner diameter (ID), 7.30m long pipe section mounted at six alterable inclination angles (0°, 15°, 30°, 45°, 60° and 75°:). The test section made from acrylic glass is outfitted with a differential gauge, pressure transducers and a high-speed camera, for pressure drop measurement, gauge pressure measurement and flow regime visualization, respectively. Simultaneous acquisition of pressure and visual data was performed at the various pipe inclinations and different flow conditions. The study successfully demonstrated that inclination angle has a significant effect on pressure drop. It also highlights the combined effect of flow regime, inclination, and flow rate on pressure drop.