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主页 旧刊 有关人员 未来大会 American Society of Thermal and Fluids Engineering

ISSN 在线: 2379-1748

ISBN 打印: 978-1-56700-517-2 (Flash drive)

5-6th Thermal and Fluids Engineering Conference (TFEC)
May, 26–28, 2021 , Virtual

NUMERICAL INVESTIGATION OF INFLUENCE OF SURFACE DEPOSITION OF NANOPARTICLES IN TUMORS DURING NANOFLUID INJECTION

Get access pages 627-634
DOI: 10.1615/TFEC2021.bio.036675

摘要

In nanoparticle-assisted thermal ablation, the delivery of nanoparticles forms a vital element for attaining optimum temperature elevations in the tumor while sparing surrounding healthy tissue. This paper uses numerical modelling to evaluate the spatiotemporal distributions of nanoparticles inside the tumor region when intra-tumoral/local injection of nanoparticles is considered. The transport of nanoparticles inside the tumor is governed by the advection-diffusion phenomenon combined with porous media theory by considering various flow influencing parameters like injection rate, tumor volume, diffusion rate, nanoparticle size, tissue porosity, and needle diameter. During the injection process, nanoparticles bind on the solid structure of tissue and hence have varying concentration distribution within the tissue. The deposition of nanoparticles is mainly affected by the particle size, local fluid velocity and the structure of the tissue. Obtaining an effective distribution of nanoparticles requires a more detailed understanding of the effect of surface deposition in tissue, and it will be quantified by treating deposition as a concentration dependent reaction. This study evaluates the nanoparticle concentration within the tumor, more specifically, investigates the influence of deposition of particles on the cell surface during infusion of nanoparticles within the tissue. The results indicate that the nanoparticle deposition leads to non-uniform nanoparticles distribution and the nanoparticles concentration decreases on increasing the infusion rate, as the surface deposition of nanoparticles increased by increasing the injection rate.
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