The COVID-19 pandemic has struck the global industry. Airflow in an enclosed space is one of the main factors in the spread of this virus. When combined with personal protective equipment, proper air ventilation can reduce the spread of this airborne virus. Potential sources of contaminant accumulation are stagnant locations of air in a plant. It is, therefore, necessary to first identify these hot spots. It will then allow proper airflow by avoiding stagnant points by moving machines, equipment, and people working in the areas. This type of CFD study will set the benchmark for future plant machine layout standards in this pandemic background. The work discussed here is a case study on a small pharmaceutical in Paraguay. The CFD results showed detailed information on flow patterns and velocity profiles in the analyzed production environment. This helped industry management to reopen work areas and keep their operators safe.