DEVELOPMENT OF A SINGLE-PHASE BLOOD-MIMICKING FLUID WITH THE RHEOLOGICAL PROPERTIES OF HUMAN BLOOD
In vascular bio-modeling research, a blood-mimicking fluid is commonly used as the working fluid to model the flow of human blood accurately. The mimicking fluid's dynamic viscosity-shear rate curve should follow an analogous non-Newtonian behavior trend of human blood. This enables researchers to simulate blood flow accurately in microfluidic systems that are to be used for medical instruments without the need to obtain biocertification to experiment with real human blood. The objective of this work is to develop a blood-mimicking fluid that simulates the non-Newtonian dynamic viscosity-shear trend reported in the literature using inexpensive ingredients. Xanthan gum, Glycerol, Ethanol, and NaCl were mixed in an aqueous solution in different weight fractions percentages to closely achieve the desired non-Newtonian dynamic viscosity-shear trend of human blood reported in literature. The effects of each one of the used ingredients with respect to its mass fractions on the rheological trend of the developed fluid were further investigated, leading up to the ideal mass fraction composition of the most trend matching BMF.