Some studies in recent years have shown the possibility that CO₂ could be a potential alternative refrigerant for R-23 in ultra-low temperature refrigeration systems. However, there maybe exists dry ice blockage in the carbon dioxide sublimation system, which is a fatal injury to the operation of the system. In this study, the use of extra carrier fluid with flow to enhance heat transfer and reduce blockage is proposed, and compares the properties and character of several carrier fluids (Novec-649, R1234ze(Z), R245fa, R123, and R125) together with carbon dioxide. Simulation software Ansys fluent was used to analyze the improvement of dry ice blockage with carrier fluid in T-junction at a sublimation temperature of -78.5°C, and the volume fraction of solid carbon dioxide in inlet and outlet. The result shows that the carrier fluids have a great potential to improve pipe blockage of the CO₂ sublimation system.