Departement of Mechanical Engineering, IIT Kanpur, Kanpur, 208016, India; Department of Mechanical Engineering, College of Engineering, Dawadmi, Shaqra University, KSA
School of Mechanical Engineering, Sastra University, Tamil Nadu, 613401, India
Pradipta Kumar Panigrahi
Gas hydrate laboratory, Department of Mechanical Engineering, Indian Institute of Technology Kanpur, Kanpur-208016, India
In magnetic drug targeting (MDT), therapeutic magnetic nanoparticles (MNPs) are injected into blood stream
and external magnetic field is then applied to localize them around the malignant tissue. The present study
reports the in vitro localization of curcumin-oleic acid loaded iron oxide nanoparticles (CU-OA-IONPs) at the
target site inside a micro-capillary (500 × 500 μm2 square cross section) in the presence of an externally applied magnetic field produced by a permanent magnet (Br = 150 mT). Application of magnetic field leads to transportation of CU-OA-IONPs towards the target site and form aggregate of CU-OA-IONPs at the target site adjacent to the magnet. COMSOL simulations were also carried out for the localization of IONPs at the target site inside a micro-capillary to validate the experimental results. A good agreement is observed between the simulation results with that of experimental results for the localization of IONPs at the target site during MDT.