A numeric study was performed that compares the performance of heat exchangers using enhanced heat transfer tubes to the performance of heat exchangers that use smooth surface tubes. Heat transfer enhancement is an important factor in obtaining energy efficiency improvements in all heat transfer applications. Utilization of enhanced heat transfer tubes is an effective method that is utilized in the development of high performance thermal systems. Current energy demands and the desire to increase efficiencies of systems have prompted the development of enhanced heat transfer surfaces. Enhanced heat transfer tubes are widely used in many areas (refrigeration, air-conditioning, etc.) in order to reduce cost and create a smaller application footprint. It is important to investigate and compare relevant heat exchanger designs using enhanced surface tubes in industrial applications and compare that performance to smooth tubes. Results include performance predictions produced using HTRI Exchanger Suite [1].